1.

Specialization

Physiology, Developmental Biology & Embryology, Biotechnology, Genetics, Cell&Molecular Biology, Genetic Engineering

2. Research ID

a) Google Scholar:ZD4IA

b) ORCID: ID 0000-0002-6243-8388 (https://orcid.org/0000-0002-6243-8388)

c) Scopus: 57213378705

d) Others:

     LinkedIn: https://www.linkedin.com/in/ravi-prakash-yadav-b334261a/

3.

Teaching: B. Sc. B.Ed Zoology and M.Sc. Environmental Science

Teaching Interests

Expertise in core biological sciences, including Cell Biology, Molecular Biology, Developmental Biology, Physiology, Genetics, and Immunology. I deliver advanced courses in Biochemistry, Biotechnology, Genetic Engineering, and Laboratory/Research Methodology, combining theory with practical application. My interests extend to emerging topics such as infectious diseases, metabolic and lifestyle disorders, and cutting-edge protein and antibody engineering. Committed to developing innovative curricula and digital e-content, I aim to enhance learning experiences across secondary, undergraduate, and postgraduate education levels

4.

RESEARCH  

Research Area & Interests

My research focuses on elucidating the molecular mechanisms of multidrug resistance (MDR) in cancer to improve therapeutic efficacy. I investigate protein-protein and protein-drug interactions to identify new therapeutic targets and design small molecules for precision drug delivery. Structural and functional characterization of large biomolecular assemblies, including their cellular localization, is a key focus area. In viral biology, I explore host-pathogen interactions, particularly how viral membrane proteins contribute to infection cycles, using advanced structural biology techniques and cellular imaging.

Key themes include:

• Understanding cancer progression and overcoming chemotherapy resistance by studying molecular determinants like drug-efflux pumps and apoptotic pathway alterations.

• Designing protein-based therapeutics that modulate ligand-receptor interactions critical for cell growth, immune response, and apoptosis—applying rational design and directed evolution for enhanced therapeutic potential.

• Investigating the 14-3-3 protein family’s role in cell signaling, tumor suppression, and its potential as a target for novel cancer therapies, with a focus on isoform-specific interactions.

• Study investigates how HPV proteins interfere with cellular tumor suppressor pathways, contributing to cervical cancer. By understanding virus–host protein interactions, new strategies for drug development and intervention are targeted.

Vision

My vision is to cultivate a research-driven, inquiry-based learning environment where foundational biological knowledge is integrated with hands-on experience and critical analysis. I strive to innovate education through curriculum advancement and cutting-edge research, preparing students and educators to excel as leaders in interdisciplinary biological sciences.

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Doctoral Study (2007-2012)

Conducted biophysical studies on protein folding and crystallography at Banaras Hindu University (BHU), focusing on how polypeptides self-assemble into functional three-dimensional structures essential for enzyme and antibody activity. Investigated folding kinetics and molecular interactions using experimental and computational methods to establish models linking protein structure and function.

Collaborated as DAAD Fellow at CSSB-HZI-DESY, Hamburg, Germany, solving high-resolution structures of dimeric autoinhibited DAPK2 kinase and human myelin protein P2, revealing mechanisms regulating apoptosis and membrane binding via X-ray crystallography, SAXS, spectroscopy, and simulations.

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Research Experience

1. Scientist III, Electron Microscope Facility, AIIMS, New Delhi (2022-2023)
   Established advanced cryo-electron microscopy platforms (SPA, cryo-ET) for high-resolution macromolecular and cellular imaging. Investigated protein interactions in disease pathways and developed nano-fluorescence-based cancer diagnostics. Designed nanotechnology-driven targeted drug delivery systems for cancer therapies.

2. Assistant Research Scientist, Molecular Physiology & Biophysics, University of Iowa, USA (2019-2021)

Studied visual transduction, focusing on maturation and functional folding of phosphodiesterase 6 (PDE6) via chaperone complexes (AIPL1-HSP90). Characterized structural mechanisms governing photoreceptor signaling, advancing understanding of retinal degenerative diseases, and identifying therapeutic targets for blindness treatment.

3. Postdoctoral Research

• University of Iowa, Carver College of Medicine (2014-2018)

  Explored the molecular basis of retinal diseases, emphasizing PDE6, AIPL1, and Transducin G protein roles in photoreceptor function. Investigated pathogenic mutations affecting protein folding and trafficking, solved key protein domain structures, and linked molecular defects to retinal degeneration.

• Indiana University-Purdue University Indianapolis (IUPUI), USA (2012-2013)
  Researched cancer multidrug resistance (MDR), focusing on mechanisms like drug efflux transporter overexpression and altered intracellular targets. Screened small molecules to reverse MDR, aiming to improve chemotherapy effectiveness and reduce tumor relapse

   

a. Project

b.  

I. Publications

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1. Jitendra Kumar, Shravan K Uppulapu, Sujata Kumari, Kanika Sharma, William Paradee, Ravi P Yadav, Vikas Kumar, Santosh Kuma. p66Shc Mediates SUMO2-induced Endothelial Dysfunction. E Life (2025), (Preprint)  https://doi.org/10.7554/eLife.106344. 

2. Kemant Pratap, Manish Rawat, Ravi P. Yadav, Atul Kumar “Azole-Substituted Triazole Formation through www.chemistryselect.org Organocatalytic Cycloaddition of β-keto Azoles and Aryl Azide”. ChemistrySelect, (2024), 9, e202402928 (1 of 5), ISSN no.: 2365-6549https://doi.org/10.1002/slct.202402928

3. Shikha Chaudhary, Ravi P. Yadav,.., Subhash Chandra Yadav. “Aplastic anemia patients with severe COVID-19 showed abnormal ultrastructure features on type II pneumocytes of lungs”.  IJBB (2023), ISSN no. 0975-0959, https://doi.org/10.56042/ijbb.v60i8.4293

4. Dhiraj Srivastava^#, Ravi P. Yadav^#, Sneha Singh, Kimberly Boyd, and Nikolai O. Artemyev “Unique interface and dynamics of the complex of HSP90 with a specialized cochaperone AIPL1” Structure (2023) (^#contributed equally), ISSN No.0969-2126,  doi:https://doi.org/10.1016/j.str.2022.12.014.

5. Shikha Chaudhary, Ravi P. Yadav, Shailendra Kumar, Subhash C Yadav“Ultrastructural study confirms the formation of single and heterotypic syncytial cells in bronchoalveolar fluids of COVID-19 patients’’, Virology Journal (2023), ISSN No. 1743-422X, doi:https://doi.org/10.1186/s12985-023-02062-7

6. Ravi P. Yadav, Kimberly Boyd, and Nikolai O. Artemyev "Molecular insights into the maturation of phosphodiesterase 6 by the specialized chaperone complex of HSP90 with AIPL"  JBC (2022) V 298(3), p 1-12,  ISSN No. 1083-351X doi:https://doi.org/10.1016/j.jbc.2022.101620

7. J Wesley Maddox, Kate L Randall, Ravi P. Yadav, Brittany Williams, Jussara Hagen, Paul J Derr, Vasily Kerov, Luca Della Santina, Sheila A Baker, Nikolai Artemyev, Mrinalini Hoon, and Amy Lee " A dual role for Ca1.4 Ca channels in the molecular and structural organization of the rod photoreceptor synapse".e Life (2020), 9:e62184 ISSN No. 2050-084Xdoi:https://doi.org/10.7554/eLife.62184

8. Dhiraj Srivastava, Ravi P. Yadav, Shivangi M Inamdar, Zhen Huang, Kimberly Boyd, and Nikolai O Artemyev “Transducin partners outside the phototransduction pathway” Front. Cell. Neurosci (2020), V 14, p 1-9.ISSN No.1662-5102  doi:https://doi.org/10.3389/fncel.2020.589494.

9. Ravi P. Yadav, Kimberly Boyd, Liping Yu, and Nikolai O. Artemyev. “Interaction of the TPR-domain of aryl hydrocarbon receptor-interacting protein-like 1 with the regulatory Pγ subunit of phosphodiesterase 6”, JBC (2019) V 294 (43), p 15795-15807, ISSN No. 1083-351Xdoi.10.1074/jbc.RA119.010666.

10. Maxim Sokolov, Ravi P. Yadav, Celine Brooks, and Nikolai O. Artemyev. “Chaperone and Retinal Disorder” Advances in Protein Chemistry & Structural Biology (2019), V 114, p 85-117. ISSN/ ISBN /Ref No. 1876-1623, doi. https://doi.org/10.1016/bs.apcsb.2018.09.001

11. Liping Yu, Ravi P Yadav, and Nikolai O Artemyev. “NMR resonance assignments of the TPR domain of human aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1)”  Biomolecular NMRAssignments(2018). ISSN/ISBN /Ref No. 1874-270X doi.10.1007/s12104-018-9856-x

12. Ravi P. Yadav and Nikolai O. Artemyev. “AIPL1: a specialized chaperone for the phototransduction effector.” Cellular Signaling (2017) V 40, 183-190, ISSN No. 0898-6568, doi.10.1016/j.cellsig.2017.09.014.

13. Ravi P. Yadav, Lokesh Gakhar, Liping Yu, and Nikolai O. Artemyev. “Unique structural features of the AIPL1-FKBP domain that support prenyl lipid binding and underlie protein malfunction in blindness.” PNAS (2017) 114 (32), E6536-E6545. ISSN No. 1091-6490, doi. https://doi.org/10.1073/pnas.1704782114

14. Liping Yu, Ravi P Yadav, and Nikolai O Artemyev “NMR resonance assignments of the FKBP domain of human aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) in complex with a farnesyl ligand” Biomolecular NMR Assignments (2017) 11, 111–115. ISSN/ISBN /Ref No. 1874-270X, doi:10.1007/s12104-017-9730-2

15. K N Gopalakrishna, Kimberly Boyd, Ravi P. Yadav, and Nikolai O Artemyev. “Aryl hydrocarbon receptor-interacting protein-like 1 is an obligate chaperone of phosphodiesterase 6 and is assisted by the γ-subunit of its client.” JBC(2016) 291(31), 16282-291. ISSN No.1083-351X,doi. 10.1074/jbc.M116.737593.

16. Ravi P. Yadav, A Majumder, L Gakhar, and Nikolai O Artemyev. “Extended conformation of the proline-rich domain of human aryl hydrocarbon receptor-interacting protein-like 1: implications for retina disease.”JNeurochem. (2015) 135 (1), 165-175. ISSN No. 1471-4159, doi. 10.1111/jnc.13223.

17. Salla Ruskamo^#, Ravi P. Yadav^# …, Inari Kursula, and Petri Kursula. “Atomic-resolution view into structure-function relationships of the human myelin peripheral membrane protein P2.”Acta Crystallogr. D Biol. Crystallogr.(2014). (^#contributed equally). ISSN No. 1399-0047, doi. 10.1107/S1399004713027910.

18. Ravi P. Yadav, A.K. Patel, and M.V. Jagannadham. “Neriifolin S, a dimeric serine protease from Euphorbia neriifolia: Purification and Biochemical characterization.”  Food Chemistry (2012). ISSN No. 0308-8146, doi. 10.1016/j.foodchem.2011.11.107.

19. A.K. Patel^#Ravi P Yadav^#, , Viivi Majava, Inari Kursula and Petri Kursula. “Structure of the Dimeric Autoinhibited Conformation of DAPK2, a Pro-Apoptotic Protein Kinase.” J. Mol. Biol.  (2011) 409, 369–383. (^#contributed equally). ISSN/ISBN /Ref No. 0022-2836, doi.10.1016/j.jmb.2011.03.065

20. Ravi P. Yadav,A.K. Patel, andM. V. Jagannadham “Purification and Biochemical characterization of a chymotrypsin like serine protease from Euphorbia neriifloia L.”Process Biochemistry (2011) 46, 1654–1662. ISSN/ISBN /Ref No. 1359-5113, doi. 10.1016/j.procbio.2011.05.013

21. A.K. Patel,V. K Singh, Ravi P Yadav, and M.V. Jagannadham. “Purification and characterization of new chitinase from Ipomoea carnea.” Process Biochemistry,(2010) 45 (5), 675-681. ISSN/ISBN /Ref No. 1359-5113, doi. 10.1016/j.procbio.2009.12.016

22. A.K. Patel,V.K. Singh, Ravi P Yadav, A.J. Moir, and M.V. Jagannadham, “ICChI, a glycosylated chitinase from latex of Ipomea carnea.” Phytochemistry (2009) 70 (10), 1210-1216. ISSN/ISBN /Ref No. 0031-9422, doi. 10.1016/j.phytochem.2009.07.005

    Details of all publications: ORCID:  (https://orcid.org/0000-0002-6243-8388),

     

     

     

.II. Protein Data Bank Deposition (PDB):

5.

Seminars/Conferences/Symposium/Workshops/Poster & Paper Presentations

• Oral Talk at the International Conference on Molecular and Cellular Electron Tomography, AIIMS, New Delhi (April 21–22, 2023). "Aryl Hydrocarbon Receptor Protein Like 1 (AIPL1)"

• Attended International Conference on Molecular and Cellular Electron Tomography & Workshop on Biological Specimens, AIIMS, New Delhi (April 17–22, 2023).

• Paper Presentation at the International Conference on Electron Microscopy (EMSI 2023), Delhi University (Feb 8–10, 2023). "Ultrastructural study confirms the formation of multiple types of syncytial cells in bronchoalveolar fluids of COVID-19 patients."

• Completed the EMBO Practical Course on Cryo-EM Image Processing (CEM3DIP), IISER Pune (Dec 4–16, 2022).

• Paper Presentation at the Second Annual AIIMS Research Day, AIIMS, New Delhi (Oct 17–18, 2022). "Severe SARS-CoV-2 infection reveals the multiple types of syncytial cells in the BALF of COVID-19 patients."

• Attended National Workshop on "Electron Tomography of Biological Specimens" held at Electron Microscope Facility, AIIMS, New Delhi, India from May 09 to 13, 2022.

• Attended Bringing Chemistry to Medicine Symposium Virtual Conference (Transcription Therapy and Frontiers in Chemical Biology), St. Jude, USA (July 22–23, 2021).

• Attended Advances in COVID-19 Prevention and Treatment Enabled by Structural Biology Research, Advance Photon Source, USA (May 11–12, 2021).

• Attended Bringing Chemistry to Medicine Symposium Virtual Conference (Transcription Therapy & Chemical Biology), St. Jude, USA (Sept 24–25, 2020).

• Paper Presentation at the FASEB-The Biology & Chemistry of Vision Science Research Conferences, Colorado (June 24–28, 2019)."Role of the TPR-domain of Aryl hydrocarbon receptor-interacting protein-like 1 and its function as PDE6 chaperone."

• Paper Presentation at the ARVO Annual Meeting, Vancouver, Canada (April 28–May 2, 2019)."Role of the TPR-domain of AIPL1 in its function as PDE6 chaperone."

• Paper Presentation at The ACA (American Crystallographic Association) Meeting, Toronto, Canada (July 20–24, 2018). "Molecular Mechanism of AIPL1 and its TPR domain in Leber congenital amaurosis 4 (LCA 4)."

• Paper Presentation at the FASEB-The Biology & Chemistry of Vision Science Research Conferences, Colorado (June 25–30, 2017)."Critical role of the insert region of AIPL1-FKBP domain in chaperoning PDE6."

• Paper Presentation at the ARVO Annual Meeting, Seattle, Washington (May 1–5, 2016)."Delineation of the farnesyl binding site of AIPL1 by NMR."

• Paper Presentation at the ARVO Annual Meeting, Denver, Colorado (May 3–7, 2015)."Probing the role of C-terminal region of human AIPL1."

• Attended International Symposium on Molecular Therapeutics and Translational Medicine, BHU Varanasi (Feb 2012).

• Attended Symposium on recent trends in Biophysics and workshop on emerging techniques of Biophysics, BHU Varanasi (Feb 2010).

• Attended National Symposium on Cellular and Molecular Biophysics (NCMB), CCMB Hyderabad (Jan 2009).

• Attended a Seminar and workshop on Metabolic network and drug design,  Banaras Hindu University, Varanasi, U.P., India, December 2008.

• Attended Indo-German Scientific Workshop in the fields of Molecular Biology of Infectious Diseases, Plant Biochemistry & Biotechnology, Environmental Research & Nanotechnology, held at University of Hyderabad, A.P., India, November 2004.

            Curriculum & Resource Person Roles

• Served as Resource Person in the Two-Day Workshop on Finalization of Curriculum and Syllabus for ITEP B.Sc. B.Ed. (Zoology Major), RIE Mysore (June 18–19, 2025).

• Contributed to the training of Key Resource Persons (KRPs) from Karnataka and Telangana on Experimental and Project-Based Learning (Classes IX and X), RIE Mysore (Feb 24–28, 2025).

• Served as Rapporteur at the National Conference on Innovative Experiences in School Board Career Development Programme, RIE Mysore (Jan 30–31, 2025).

• Served as Resource Person for training on Chemical Safety and Disposal Protocols in Academic Institutions, RIE Mysore (Dec 13, 2024).

• Served as Resource Person for Training Programme on Experiment-Based Learning and Project Method of Learning Science (Middle School Stage), RIE Mysore (Dec 9–13, 2024).

• Participated in Capacity Building Workshop for Master Trainers on Learning–Teaching Material (Foundational & Preparatory Stages), RIE Mysore (Oct 22–24, 2024).

• Attended Workshop on Content Design and Scripting for E-Content Development (aligned with NEP 2020), RIE Mysore (Oct 19, 2024).

• Served as Resource Person for the Training Programme on Experiment-Based Learning and Project Method of Learning Science (Middle School Stage), RIE Mysore (Sept 25–27, 2024).

• Attended Orientation Programme on NCERT Educational Kits for Key Resource Persons of States/UTs, RIE Mysore.

6.

Development 

• Developed an experiment- and project-based module on The Fundamental Unit of Life for KRPs of Karnataka and Telangana (2025, RIE Mysore).

• Developed an experiment and project-based module on Exploring Animal Diversity through Zoology Museum Visit for KRPs of Karnataka and Telangana (2025, RIE Mysore).

• Developed a module on Biodiversity and Its Conservation: A Project-Based Learning Approach (2024, RIE Mysore).

• Developed a module on Understanding Physiological Processes and Homeostasis: A Project-Based Learning Approach (2024, RIE Mysore).

7.

Training

• Completed 6-day residential Short-Term Programme on 'Evaluation Research and Programme Evaluation,' MMTTC, RIE-NCERT Mysore (Sept 22–27, 2025).

• Completed “21-day Orientation Programme for Faculty Members”, organized by the Department of Teacher Education, NCERT (March 3–28, 2025).

• Completed Faculty Induction Programme, organized by IIM Nagpur & NCERT (Feb 3–7, 2025).

• Participated in Sensitization Programme on Inclusion of the Transgender Community in School Education, NCERT, New Delhi (June 2025).

8.

Extension

• Conducted Vidya Pravesh Evaluation Study in Dakshina Kannada district, Karnataka, as part of the NCERT's national foundational learning assessment (2025).

• Conducted Biological Study Tour for Semester IV students (March 7–9, 2025), including St. Mary’s Island, Manipal Anatomy Museum, Pilikula Biological Park, Krishi Vigyana Kendra (Brahmavara), and Fisheries.

• Conducted Biological Study Tour for Semester IV students (April 5–7, 2024), covering educational and natural sites in Mangaluru and Udupi, including St. Mary’s Island and Manipal University.

• Organized International Conference: “Molecular and Cellular Electron Tomography,” AIIMS, New Delhi, April 21–22, 2023.

• Organized National Workshop: “Electron Tomography of Biological Specimens,” AIIMS, New Delhi, April 17–22, 2023.

• Organized National Workshop: “Electron Tomography of Biological Specimens,” Electron Microscope Facility, AIIMS, New Delhi, May 9–13, 2022.

9. Other information

a.Other Academic Responsibilities 

• Section Head, Zoology, Department of Education in Science and Mathematics, RIE Mysore (since Feb 2024).

• In-Charge Head, Department of Education in Science and Mathematics, RIE Mysore.

• Member of the Board of Examiners, University of Mysore, for RIE's B.Sc. B.Ed., examinations.

• Hostel Warden, RIE-NCERT Mysuru (since Feb 2024).

• Co-coordinator, Admission Committee, and prepared Merit List–1 for RIE Mysore B.Sc. B.Ed. admissions (CEE 2025–26).

• Co-coordinator, Admission Committee, and prepared Merit List–1 for RIE Mysore B.Sc. B.Ed. admissions (CEE 2024–25).

• Conducted Post-Internship Assessment for VII Semester B.Sc. B.Ed. (CBZ) students (Academic Year 2025–26).

• Conducted Internship Supervision and Assessment for VII Semester B.A. B.Ed., B.Sc. B.Ed., and M.Sc. Ed. students at JNV Cluster 6 (2025).

• Conducted Internship Supervision and Assessment for VII Semester B.A. B.Ed., B.Sc. B.Ed., and M.Sc. Ed. students at JNV Cluster 3 (2024).

• Assessed School Internship Programme–II for B.Ed. (Semester II) students.

• Conducted assessments for School Attachment Programmes (SAP–I to IV) for B.Sc. B.Ed., B.A. B.Ed., and M.Sc. Ed. students.

b. Honors/Academic Achievements/Travel grants

• Recipient ofKTEF Career-Starter Research Grant

• Awarded the prestigious DAAD Research Fellowship from the German Academic Exchange Service (2010).

• Qualified for all three major national research fellowships/exams in India (2007):

• DBT Junior Research Fellowship (BET-JRF)

• ICMR Junior Research Fellowship (ICMR-JRF)

• Joint CSIR-UGC-National Eligibility Test (NET)

• Qualified Graduate Aptitude Test in Engineering (GATE-2006) in Life Science.

• Recipient of a fellowship for DBT M.Sc. Biotechnology Program (2004–2006).

• Awarded FASEB Travel Grant to attend The Biology & Chemistry of Vision Science Research Conferences (Colorado, 2017 & 2019).

• Recipient of Travel Grant and Partial Funding for the EMBO practical course on Cryo-EM and 3D Image Processing (CEM3DIP), IISER Pune, India (Dec 2022).